50
4
Cat. No. | Product Name | Target | Signaling Pathways |
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T9251 |
Fedratinib hydrochloride hydrate
TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate |
Apoptosis; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) 是一种选择性的,ATP 竞争性和具有口服活性的JAK2抑制剂,对于JAK2和JAK2V617F 激酶的IC50均为 3 nM。它可诱导癌细胞凋亡,可研究骨髓增生性疾病。 | |||
T8404 |
Kasugamycin hydrochloride hydrate
Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物 |
Antibacterial; Antibiotic | Microbiology/Virology |
Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate)) 是一种能结合 30s 和 70s 核糖体,但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸破坏 tRNA 结合并抑制典型翻译起始。 | |||
T2593 |
Eflornithine hydrochloride hydrate
Difluoromethylornithine hydrochloride hydrate,α-difluoromethylornithine hydrochloride hydrate,依氟鸟氨酸盐酸盐一水合物,Eflornithine hydrochloride,MDL-71782 hydrochloride hydrate,DFMO hydrochloride hydrate,RMI-71782 hydrochloride hydrate,Eflornithine hydrochloride Monohydrate |
Decarboxylase | Metabolism; Others |
Eflornithine hydrochloride hydrate (RMI-71782 hydrochloride hydrate) 是一种特异性的、不可逆的酶鸟氨酸脱羧酶抑制剂。它可用于研究非洲锥虫病和女性面部毛发过度生长。 | |||
TQ0304 |
Metixene hydrochloride hydrate
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AChR | Neuroscience |
Metixene hydrochloride hydrate 具有潜在的抗胆碱能活性,对苯甲酸奎宁环 (QNB) 与毒蕈碱受体的结合有抑制作用,IC50 和 Ki 值分别为 55 nM 和 15 nM。 Metixene hydrochloride hydrate 可用于预防和治疗帕金森。 | |||
T2191 |
Tacrine hydrochloride (hydrate)
Tacrine,他克林盐酸盐水合物,Tacrine hydrochloride hydrate,Tetrahydroaminacrine,Tetrahydroaminoacridine |
AChR; AChE | Neuroscience |
Tacrine hydrochloride hydrate (Tetrahydroaminacrine) 是一种乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂,它们的IC50值分别为 31 nM 和 25.6 nM。 | |||
T0038 |
Doxapram hydrochloride hydrate
多沙普仑盐酸一水合物,盐酸多沙普仑,Doxapram hydrochloride monohydrate,Doxapram HCl |
Potassium Channel | Membrane transporter/Ion channel |
Doxapram hydrochloride hydrate (Doxapram HCl) 是 TASK-1,TASK-3和 TASK-1/TASK-3异二聚体通道的抑制剂,EC50分别为410 nM,37 μM 和9 μM。 | |||
T1144L |
Lidocaine Hydrochloride hydrate
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EGFR; Sodium Channel | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
Lidocaine Hydrochloride hydrate 是一种酰胺类局部麻醉剂,具有抗炎作用。 | |||
T4990 |
Cefcapene pivoxil hydrochloride hydrate
Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯 |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefcapene pivoxil hydrochloride hydrate 是一种头孢菌素的前药,具有口服活性和广谱抗菌活性。它可研究掌跖脓疱病等感染性疾病。 | |||
T8385 |
Metoclopramide hydrochloride hydrate
盐酸甲氧氯普胺,甲氧氯普胺盐酸水合物,Metoclopramide monohydrochloride monohydrate |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。 | |||
T38323 |
A-943931 (hydrochloride hydrate)
|
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A-943931 is a histamine H4receptor antagonist (Ki= 3.8 nM).1In vivo, A-943931 inhibits scratching induced by clobenpropit in mice (ED50= 26 μmoles/kg, i.p.). 1.Milicic, I., Witte, D.G., Miller, T.L., et al.Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activityFASEB J.23(S1)760.768-760.768(2009) | |||
T36779 |
NG 25 (hydrochloride hydrate)
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NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv... | |||
T69002 |
Zimeldine hydrochloride hydrate
|
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Zimeldine hydrochloride hydrate is a serotonin uptake inhibitor that was formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of Guillain-Barre Syndrome associated with its use. | |||
T35567 |
BIX01294 (hydrochloride hydrate)
|
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The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other ... | |||
T39864 |
CDK7-IN-2 hydrochloride hydrate
CDK7-IN-2 hydrochloride hydrate |
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CDK7-IN-2 hydrochloride hydrate (Example 6) is a highly effective and specific inhibitor of the CDK7 enzyme. This compound exhibits significant anti-cancer properties. | |||
T63505 |
Tivozanib hydrochloride hydrate
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Tivozanib hydrochloride hydrate 是选择性的、有效的、口服具有活力的 VEGFR 酪氨酸激酶抑制剂,能够作用于 VEGFR-1 (IC50: 0.21 nM)、VEGFR-2 (IC50: 0.16 nM)、VEGFR-3 (IC50: 0.24 nM)。Tivozanib hydrochloride hydrate 能够抑制肿瘤组织中的血管生成和血管通透性,并具有抗肿瘤作用,对转移性肾细胞癌 (RCC) 具有研究潜力。 | |||
T81445 |
PKRA83 hydrochloride hydrate
PKRA7 hydrochloride hydrate |
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PKRA83 hydrochloride hydrate是一种高效的促动力拮抗剂,与PK2及其受体PKR1和PKR2进行竞争性结合。该化合物在抑制PK2受体方面表现出色,其对PKR1和PKR2的IC50值分别为5.0 nM和8.2 nM。此外,PKRA83 hydrochloride hydrate还具备抗癌、抗关节炎以及抗血管生成的活性,并能够穿透血脑屏障。 | |||
T70108 | Fasudil hydrochloride hydrate | ||
Fasudil hydrochloride hydrate is an HCl salt of Fasudil -- a Rho-kinase (ROCK) inhibitor that has been shown to be effective in hindering the development of mature Cerebral Cavernous Malformation (CCM) lesions as well as reducing portal venous pressure in cirrhotic rats. | |||
T13413 |
Zoniporide hydrochloride hydrate
CP-597396 hydrochloride hydrate |
Others | Others |
Zoniporide hydrochloride hydrate is a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor. Zoniporide hydrochloride hydrate inhibits human NHE-1 with IC50 of 14 nM. | |||
T69628 | Iptacopan hydrochloride hydrate | ||
Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor. | |||
T28515 | Remoxipride hydrochloride (hydrate) | ||
Remoxipride hydrochloride (hydrate) is a potent D2DR (dopamine D2 receptor) antagonist and antipsychotic. | |||
T68371 |
Rolapitant hydrochloride hydrate
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Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of ... | |||
T0788L |
Spectinomycin dihydrochloride pentahydrate
盐酸大观霉素五水合物,Trobicin,Spectogard,Spectinomycin hydrochloride hydrate |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Spectinomycin dihydrochloride pentahydrate (Spectogard) 是一种广谱氨基环糊精抗生素,可以抑制多种革兰氏阳性和革兰氏阴性生物的生长。 | |||
T22412 |
Quinacrine hydrochloride hydrate
Mepacrine Dihydrochloride Dihydrate,米帕林盐酸盐,Quinacrine Dihydrochloride Dihydrate |
Others | Others |
Quinacrine, a dye of the acridine family, has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug. | |||
T8443L |
MCI-225 hydrochloride hydrate
AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026 |
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MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom | |||
T33986 |
Phenol, m-(1-(p-hydroxyphenethyl)-3-isopropyl-3-pyrrolidinyl)-, hydrochloride, hydrate
|
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Phenol, m-(1-(p-hydroxyphenethyl)-3-isopropyl-3-pyrrolidinyl)-, hydrochloride, hydrate is a bioactive chemical. | |||
T62243 |
Bepridil hydrochloride hydrate
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Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) 是一种长效的、非选择性的钙离子通道 (Ca+channel) 拮抗剂。Bepridil hydrochloride hydrate 是一种钠离子、钾离子通道 (Na+,K+channel) 抑制剂,也是心脏 Na+/Ca2+交换 (NCX1) 抑制剂。Bepridil hydrochloride hydrate 具有抗心绞痛和抗 I 型心律失常作用,能够用于研究心血管疾病。 | |||
T63105 | Topotecan hydrochloride hydrate | ||
Topotecan hydrochloride hydrate 是一种口服具有活力的拓扑异构酶 I (Topoisomerase I) 抑制剂,具有抗癌作用。Topotecan hydrochloride hydrate 能够将细胞周期阻滞在 G0/G1 和 S 期,并诱导细胞凋亡。 | |||
T64299 | Valacyclovir hydrochloride hydrate | ||
Valacyclovir hydrochloride hydrate 是一种有效的抗病毒剂,是一种前药,在体内可快速转化为阿昔洛韦。Valacyclovir hydrochloride hydrate 能够用于配制治疗眼部疱疹的眼部插入物。Valacyclovir hydrochloride hydrate 能够用于单纯疱疹、带状疱疹和乙型疱疹的治疗。 | |||
T63650 | Samuraciclib hydrochloride hydrate | ||
Samuraciclib (CT7001) hydrochloride hydrate 是有效的、选择性、ATP 竞争性的、口服具有活力的 CDK7 抑制剂 (IC50: 41 nM)。Samuraciclib hydrochloride hydrate 对 CDK7的选择性分别是 CDK1,CDK2 (IC50为 578 nM),CDK5 和 CDK9 的 45 倍,15 倍,230 倍和 30 倍。Samuraciclib hydrochloride hydrate 能够抑制乳腺癌细胞系的生长 (GI50: 0.2-0.3 μM),表现出有效的抗肿瘤效果。 | |||
T62382 |
Tiagabine hydrochloride hydrate
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Tiagabine hydrochloride hydrate 是一种有效、选择性的 GABA uptake 抑制剂;在突触体、神经元和神经胶质中,能够抑制 [3H] GABA 的摄取,他们的 IC50 值分别为 67,446 和 182 nM。Tiagabine hydrochloride hydrate 能够用作抗惊厥剂。 | |||
T23210 |
Quinacrine (dihydrochloride hydrate)
Quinacrine (hydrochloride hydrate) (83-89-6 free base) |
Others | Others |
Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e | |||
T64269 | LP 12 hydrochloride hydrate | ||
LP 12 hydrochloride hydrate 是一种选择性的、有效的 5-HT7 受体激动剂 (Ki: 0.13 nM)。LP 12 hydrochloride hydrate 对 5-HT7 的选择性高于 D2 受体 (Ki: 224 nM)、5-HT1A 受体 (Ki: 60.9 nM) 和 5-HT2A 受体 (Ki>1000 nM)。 | |||
T24448 |
MEN935
Adimolol hydrochloride hydrate,MEN-935,Men 935 |
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MEN935 is an antihypertensive agent. It is also a β-adrenoceptor blocker. | |||
T70107 |
Olcorolimus
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Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5 | |||
T70115 |
Pamiparib hydrate
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Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo... | |||
T63589 |
CX-6258 hydrochloride hydrate
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CX-6258 hydrochloride hydrate 是强效的、选择性的 pan-Pim 激酶抑制剂,能够作用于 Pim-1 (IC50: 5 nM)、 Pim-2 (IC50: 25 nM) 和 Pim-3 (IC50: 16 nM)。 | |||
T77221 | Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) | ||
Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) 是一种可逆的竞争性胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 抑制剂,对 Tryptase、Trypsin、uPA、Factor Xa、Thrombin 和 tPA 的Ki 值分别为 20、21、97、110、320 和 750 μM。 | |||
T70802 |
Duvelisib hydrate
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Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike oth... | |||
T30523 |
BMS-433771 HCl hydrate
BMS 433771,BMS-433771,BMS-433771 HCl,BMS433771,BMS-433771 hydrochloride |
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BMS 433771 is an effective RSV replication inhibitor in vitro. | |||
T7197L |
Fadrozole HCl hydrate
Fadrozole,CGS-16949A,Fadrozole hydrochloride hemihydrate,CGS16949A,CGS 16949A |
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Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer. | |||
T65690 | N2-Boc-L-arginine Hydrochloride Hydrate | ||
N2-Boc-L-arginine Hydrochloride Hydrate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65690,CAS号为 114622-81-0。 | |||
T70471 | Cgs 26303 | ||
Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation. | |||
T68690 |
Temiverine hydrochloride monohydrate
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Temiverine hydrochloride monohydrate is an anticholinergic drug with calcium antagonistic activity. | |||
T64500 |
2-Amino-3-mercaptopropanoic acid hydrochloride hydrate
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2-Amino-3-mercaptopropanoic acid hydrochloride hydrate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64500,CAS号为 116797-51-4。 | |||
T34950 |
Trimetoquinol HCl hydrate
Trimetoquinol hydrochloride,RO07-5965 RO-07-5965,RO 07-5965 |
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Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties. | |||
T71212 |
Lornoxicam-d4
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Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e... | |||
T66658 |
(S)-2-Amino-3-mercaptopropanoic acid hydrochloride hydrate
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(S)-2-Amino-3-mercaptopropanoic acid hydrochloride hydrate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66658,CAS号为 207121-46-8。 | |||
T6951 |
Pramipexole dihydrochloride hydrate
Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pramipexole dihydrochloride hydrate (Mirapex) 是选择性的,具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂,对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM,可用于研究帕金森综合症和腿多动综合征。 | |||
T22435 |
Tacrine hydrochloride
四氢氨基吖啶,盐酸他克林,Tacrine HCl |
Others | Others |
Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. | |||
T70472 | Filgotinib HCl hydrate | ||
Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease. |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN5283 |
L-Cysteine hydrochloride hydrate
L-Cysteine hydrochloride monohydrate,L-半胱氨酸盐酸盐一水物,L-半胱氨酸盐酸盐 一水合物 |
Others; Endogenous Metabolite | Metabolism; Others |
L-Cysteine hydrochloride hydrate (L-Cysteine hydrochloride monohydrate) 是条件必需氨基酸,是硫化氢、谷胱甘肽和牛磺酸等生物活性分子的前体。它可以抑制胃饥饿素,抑制啮齿动物和人类的食欲。 | |||
T5081 |
Adenine monohydrochloride hemihydrate
腺嘌呤盐酸盐,Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate |
Endogenous Metabolite; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Adenine monohydrochloride hemihydrate 是内源性代谢产物的一种。 | |||
T1235 |
Lincomycin hydrochloride monohydrate
洁霉素盐酸盐,林可霉素,Lincomycin hydrochloride hydrate |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Lincomycin hydrochloride monohydrate (Lincomycin hydrochloride hydrate) 是一种窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌的作用效果很好, 主要抑制细菌细胞蛋白质的合成。 | |||
T8130 |
Ciprofloxacin hydrochloride monohydrate
Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,环丙沙星盐酸盐一水合物,Ceprimax,盐酸环丙沙星(一水物),Ciloxan |
Antibacterial; Antibiotic | Microbiology/Virology |
Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) 是一种具有高效抗菌活性的氟喹诺酮类抗生素。 |